Slow depolarizing and hyperpolarizing currents which mediate bursting in Aplysia neurone R15.
نویسندگان
چکیده
منابع مشابه
Serotonin acting via cyclic AMP enhances both the hyperpolarizing and depolarizing phases of bursting pacemaker activity in the Aplysia neuron R15.
Bath application of 5-HT, at concentrations below 10 microM, enhances the amplitude of the interburst hyperpolarization in the Aplysia bursting pacemaker neuron R15. It is known that 5-HT acts via cyclic AMP to produce this effect by increasing the inwardly rectifying potassium current (IR). Here, we report that further elevating the concentration of 5-HT produces an enhancement of the depolari...
متن کاملA cyclic GMP analog decreases the currents underlying bursting activity in the Aplysia neuron R15.
Bath application of 8-parachlorophenylthio-cyclic GMP (8-pcpt-cGMP) has been shown to increase the number of action potentials per burst in the Aplysia neuron R15. Here we report that 8-pcpt-cGMP can eventually inhibit R15's bursting activity and cause the cell to exhibit slow tonic spiking activity. This action is preceded by decreases in spike frequency and in the amplitude of the interburst ...
متن کاملSimulation of the bursting activity of neuron R15 in Aplysia: role of ionic currents, calcium balance, and modulatory transmitters.
1. An equivalent circuit model of the R15 bursting neuron in Aplysia has been combined with a fluid compartment model, resulting in a model that incorporates descriptions of most of the membrane ion channels that are known to exist in the somata of R15, as well as providing a Ca2+ balance on the cell. 2. A voltage-activated, calcium-inactivated Ca2+ current (denoted the slow inward current ISI)...
متن کاملA novel slow (< 1 Hz) oscillation of neocortical neurons in vivo: depolarizing and hyperpolarizing components.
We describe a novel slow oscillation in intracellular recordings from cortical association areas 5 and 7, motor areas 4 and 6, and visual areas 17 and 18 of cats under various anesthetics. The recorded neurons (n = 254) were antidromically and orthodromically identified as corticothalamic or callosal elements receiving projections from appropriate thalamic nuclei as well as from homotopic foci ...
متن کاملAugmentation of bursting pacemaker activity by egg-laying hormone in Aplysia neuron R15 is mediated by a cyclic AMP-dependent increase in Ca2+ and K+ currents.
Release of the neuropeptide egg-laying hormone (ELH) from Aplysia bag cell neurons augments the endogenous bursting pacemaker activity of neuron R15. We have studied the ionic mechanisms underlying the effect of ELH in voltage-clamped R15 neurons. Both electrical discharge of the bag cells, which releases endogenous ELH, and application of synthetic ELH on cell R15 result in an increase in two ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1985
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1985.sp015603